AAT; deficiency screening.
Blood collection at collection point
After your order you receive instructions by email
Make an appointment at a collection point near you
Blood collection at 1,000+ locations across the Netherlands
Alpha-1 Antitrypsin (AAT) is a protein produced by the liver and plays a crucial role in protecting the lungs against damage from inflammation. It works by neutralizing enzymes such as neutrophil elastase, which, when overactive, can damage tissue in the lungs and other organs.
Testing for Alpha-1 Antitrypsin is essential for individuals showing symptoms of AAT deficiency, such as unexplained shortness of breath, chronic obstructive pulmonary disease (COPD), liver disease, or for individuals with a family history of AAT deficiency. It aids in the early detection and management of conditions related to AAT deficiency.
AAT levels in the blood can assist in diagnosing AAT deficiency, a genetic disorder that can lead to lung and liver diseases. Normal, elevated, or reduced levels of AAT can provide insight into the risk and severity of these conditions.
High AAT levels may indicate an acute phase response to inflammation or infection, where the body produces more AAT to protect the tissues. In rare cases, it might also point to a specific type of AAT that is less effective, even in high concentrations.
A low AAT level indicates a risk for the development of lung and liver diseases, particularly with exposure to smoke and other harmful substances. It is a strong indicator of AAT deficiency, a genetic disorder associated with an increased risk of developing COPD, liver disease, and in rare cases, skin conditions.
Answers to what people usually want to know.
After ordering we generate a referral letter and email you the instructions. You pick a collection point yourself and book an appointment there. Blood is drawn at the location, processed at the lab, and your result arrives digitally.
Often within a few working days. How soon you can be seen depends on how busy the location is and the type of analysis. For specialist analyses we first ship collection materials, which takes a bit longer.
At most collection points yes. Some accept walk-ins. This is clearly indicated per location. You choose the location that works best for you.
That depends on the test. Whether fasting is required, and from what time, is clearly stated in the instructions you receive after ordering. No surprises at the counter.
It varies per analysis: from same-day to a few working days. Standard values often come back quickly; analyses that go to an external lab can take a bit longer. You get an email with a link to your digital result, including a short explanation per value.
We work with 1,000+ collection points across the Netherlands. After ordering you'll see which locations near you are available and you pick where you'd like to go.
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This test is included in Dutch healthcare guidelines and is regularly used for its respective indications.
Rationale for this test
Deze test is een gevestigde diagnostische bepaling voor alfa-1-antitrypsinedeficiëntie (AATD), een erkende genetische aandoening die kan leiden tot long- en leverziekte. Internationale richtlijnen van grote respiratoire organisaties bevelen testen aan bij alle COPD-patiënten, onverklaarde chronische leverziekte, bronchiëctasieën en bij eerstegraads familieleden van patiënten met ernstige AATD. De test meet het AAT-eiwitniveau in serum en is de eerste stap in de diagnostiek van deze aandoening.
Last reviewed on
Dutch clinical guidelines and healthcare organisations
International scientific literature
We recommend consulting these independent sources before ordering a preventive health check.
Brochure on preventive health checks: careful choice, reliability, pros and cons, checklist.
Independent information about preventive health checks from the National Institute for Public Health and the Environment.
Reliable patient information about illnesses and complaints from Dutch GPs (NHG).
Public-facing website of the Dutch Society for Clinical Chemistry with explanations of blood tests and laboratory values.