Reverse T3; metabolic status and disease.
Blood collection at collection point
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Reverse T3 (rT3) is a biomarker in the blood that represents an inactive form of the thyroid hormone triiodothyronine (T3). It is produced as a byproduct of the normal metabolism of T3 and plays a role in the regulation of thyroid function.
Testing rT3 can be useful for assessing thyroid function, especially in complex cases where standard thyroid function tests, such as TSH and T4, do not provide a clear picture. It is helpful in the evaluation of patients with symptoms of hypothyroidism or hyperthyroidism, particularly when these symptoms persist despite normal test results.
rT3 levels provide insight into how the body regulates energy balance and metabolism. An abnormality of the normal rT3 value can indicate a disruption in thyroid function or an adjustment of the body to specific health conditions, such as severe illness or stress.
A high level of rT3 may indicate a condition called "Low T3 Syndrome" or a non-thyroidal illness, where there is an increased conversion of T3 to rT3. This may point to suppressed thyroid function or a reaction of the body to physical stress, starvation, infection, or other metabolic stressors.
A low level of rT3 is less common and may indicate hyperthyroidism or an excessively active thyroid function. It can also point to insufficient production of thyroid hormones due to various causes.
Answers to what people usually want to know.
After ordering we generate a referral letter and email you the instructions. You pick a collection point yourself and book an appointment there. Blood is drawn at the location, processed at the lab, and your result arrives digitally.
Often within a few working days. How soon you can be seen depends on how busy the location is and the type of analysis. For specialist analyses we first ship collection materials, which takes a bit longer.
At most collection points yes. Some accept walk-ins. This is clearly indicated per location. You choose the location that works best for you.
That depends on the test. Whether fasting is required, and from what time, is clearly stated in the instructions you receive after ordering. No surprises at the counter.
It varies per analysis: from same-day to a few working days. Standard values often come back quickly; analyses that go to an external lab can take a bit longer. You get an email with a link to your digital result, including a short explanation per value.
We work with 1,000+ collection points across the Netherlands. After ordering you'll see which locations near you are available and you pick where you'd like to go.
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The scientific support for this test within mainstream Dutch healthcare is limited. The test is not included in NHG/FMS standard guidelines.
Rationale for this test
Reverse T3 (rT3) is een inactieve metaboliet van schildklierhormoon T4. Binnen de Nederlandse reguliere zorg wordt rT3-meting niet standaard gebruikt voor schildklierdiagnostiek. De test heeft zeer beperkte klinische toepassingen en wordt alleen in uitzonderlijke gevallen ingezet, zoals bij zeldzame genetische syndromen of specifieke pediatrische tumoren. Voor de beoordeling van schildklierfunctie bij gewone klachten zijn standaard-testen (TSH, FT4, FT3) voldoende.
Last reviewed on
Dutch clinical guidelines and healthcare organisations
International scientific literature
We recommend consulting these independent sources before ordering a preventive health check.
Brochure on preventive health checks: careful choice, reliability, pros and cons, checklist.
Independent information about preventive health checks from the National Institute for Public Health and the Environment.
Reliable patient information about illnesses and complaints from Dutch GPs (NHG).
Public-facing website of the Dutch Society for Clinical Chemistry with explanations of blood tests and laboratory values.