SHBG; binding of testosterone and estradiol.
Blood collection at collection point
After your order you receive instructions by email
Make an appointment at a collection point near you
Blood collection at 1,000+ locations across the Netherlands
SHBG (Sex Hormone-Binding Globulin) is a protein produced in the blood that plays a crucial role in regulating the amount of sex hormones, including testosterone and estrogen, available to the body. It binds to these hormones, thereby influencing their activity.
An SHBG test can be useful for assessing various hormonal imbalances. It is particularly helpful when there are symptoms suggesting potential problems with sex hormones, such as unexplained fatigue, fertility issues, menstrual irregularities, or symptoms of too high or too low testosterone levels.
SHBG levels in the blood can provide insight into the amount of active sex hormones available to the body. This can assist in diagnosing conditions related to hormonal imbalance.
A high level of SHBG may indicate a reduced amount of available active sex hormones. This can cause symptoms such as reduced libido, fatigue, and muscle weakness. It may also point to underlying conditions such as hyperthyroidism or liver diseases.
A low level of SHBG suggests that there are more active sex hormones available than normal, which can lead to symptoms such as acne, excessive hair growth, and in some cases, risk of developing hormone-sensitive conditions.
Answers to what people usually want to know.
After ordering we generate a referral letter and email you the instructions. You pick a collection point yourself and book an appointment there. Blood is drawn at the location, processed at the lab, and your result arrives digitally.
Often within a few working days. How soon you can be seen depends on how busy the location is and the type of analysis. For specialist analyses we first ship collection materials, which takes a bit longer.
At most collection points yes. Some accept walk-ins. This is clearly indicated per location. You choose the location that works best for you.
That depends on the test. Whether fasting is required, and from what time, is clearly stated in the instructions you receive after ordering. No surprises at the counter.
It varies per analysis: from same-day to a few working days. Standard values often come back quickly; analyses that go to an external lab can take a bit longer. You get an email with a link to your digital result, including a short explanation per value.
We work with 1,000+ collection points across the Netherlands. After ordering you'll see which locations near you are available and you pick where you'd like to go.
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This test is included in Dutch healthcare guidelines and is regularly used for its respective indications.
Rationale for this test
SHBG is een gevestigde laboratoriumtest binnen de Nederlandse reguliere geneeskunde. De test wordt gebruikt bij de diagnostiek van hormonale disbalansen en is opgenomen in de standaard klinisch-chemische bepalingen. De klinische betekenis en referentiewaarden zijn goed gedefinieerd in Nederlandse richtlijnen en laboratoriumprotocollen.
Last reviewed on
Dutch clinical guidelines and healthcare organisations
International scientific literature
We recommend consulting these independent sources before ordering a preventive health check.
Brochure on preventive health checks: careful choice, reliability, pros and cons, checklist.
Independent information about preventive health checks from the National Institute for Public Health and the Environment.
Reliable patient information about illnesses and complaints from Dutch GPs (NHG).
Public-facing website of the Dutch Society for Clinical Chemistry with explanations of blood tests and laboratory values.