Urine
KPU (Kryptopyrrol)
Urine test for the presence of KPU/HPL complex, related to metabolic issues.
€ 80,00
Urine Home Test
How it works
- 01
Receive your collection kit
You receive a urine collection kit with clear instructions
- 02
Collect your sample
Easily collect a urine sample yourself
- 03
Mail back
Return via medical mail to the lab
This test measures
- HPL-complex
HPU, hemopyrrollactamuria (also known as KPU), is a metabolic problem/condition that occurs more frequently in women than men. HPU does not always immediately lead to symptoms, but many people eventually experience health problems. A characteristic and direct symptom of HPU is increased joint mobility (hypermobility). Especially in women, it is common to be able to bend their little finger straight back or hyperextend their thumb. Hypermobility of the jaw joint is also common.
The abbreviation HPU stands for hemopyrrollactamuria and is named after the substance excreted in the urine of people with HPU, the so-called HPL complex (Hemopyrrollactam complex). This complex chemical compound is not found elsewhere in the body and is – it is suspected – a waste product of metabolism. This excretion of HPL is accompanied by a loss of important vitamins and minerals, particularly vitamin B6, zinc, and manganese.
Because HPU binds the active form of B6 (pyridoxal-5-phosphate), it disrupts the biochemical processes in the body where this vitamin is necessary. This primarily concerns the absorption of zinc, manganese, chromium, and magnesium from our food and the metabolism of carbohydrates and fats. Zinc and manganese are essential for resistance to infections, sugar metabolism, and cartilage formation. Vitamin B6 is also involved in the production of vitamin B3, which is why this vitamin is also reduced in HPU.
HPU should not be considered an independent disease and does not develop into a specific disease, but rather into a range of (mild to severe) symptoms that can lead to certain other conditions. HPU is stress-related, both psychologically and physically.
Insufficient evidence in mainstream medicine
The underlying condition or the clinical significance of this test is insufficiently supported within mainstream Dutch medicine.
Rationale for this test
Het ziektebeeld HPU/KPU wordt binnen de Nederlandse reguliere geneeskunde niet erkend. In 2006 oordeelde de Rechtbank Den Haag dat HPU geen wetenschappelijk onderbouwde aandoening is. De test meet een stof (hemopyrrollactam) waarvan de klinische betekenis niet is aangetoond in gecontroleerd wetenschappelijk onderzoek. HPU/KPU komt niet voor in Nederlandse zorgrichtlijnen (NHG, FMS) of internationale classificatiesystemen zoals ICD-10.
Do not interpret a result from this test as a diagnosis, and always discuss with your GP which regular diagnostics are appropriate for your symptoms.
Independent information sources
We recommend consulting these independent sources before ordering a preventive health check.
- Client brochure PGO (NVvPG, September 2023)
Brochure on preventive health checks: careful choice, reliability, pros and cons, checklist.
- RIVM — Health tests
Independent information about preventive health checks from the National Institute for Public Health and the Environment.
- Thuisarts.nl
Reliable patient information about illnesses and complaints from Dutch GPs (NHG).
- Allesovertesten.nl (NVKC)
Public-facing website of the Dutch Society for Clinical Chemistry with explanations of blood tests and laboratory values.
Practical information
Frequently asked questions
How does the urine test work from A to Z?
After ordering we ship the collection kit to your home. You collect urine following the instructions, return it in the envelope, and receive your result digitally by email.
How do I collect my urine sample correctly?
Follow the included instructions, usually the midstream method in a sterile container. Pay attention to the right timing (first morning urine or random, depending on the test).
Do I need to avoid anything before collection?
For some tests yes (e.g. certain foods or supplements). Whether this applies is stated in the instructions. Read them before you start.
When and how do I receive my result?
Usually 2 to 5 working days after the lab receives your sample. You receive your laboratory report securely by email. It lists the measured values, units, reference ranges and any flags added by the laboratory.
How do I return the collection materials to the lab?
Use the supplied return envelope and place it in the letter-mail bag inside a PostNL service point yourself as soon as possible. Do not hand it to counter staff or request track & trace. The instructions supplied with your test state when it must be sent.
What if I have questions or something doesn't work?
Feel free to contact us via WhatsApp, email or phone. We're happy to help you before, during or after your test. If the collection doesn't work, we'll arrange a solution or send new materials — no hassle.
“Very positive experience”
From ordering to having my blood drawn, everything went smoothly and was well organised. I really appreciated being able to visit a blood collection location in my own town so quickly. I received clear instructions beforehand, and the results arrived promptly by email too. Very satisfied!
ElineVerified
“Good communication”
This company responds to questions thoroughly and promptly. The entire process, from requesting the test to having blood drawn and receiving the results, runs very smoothly. Overall, I am very satisfied!
Jacques QuipèreVerified
“Wide choice of tests, fast and affordable”
You can choose the tests yourself. Fast delivery and processing, clear instructions and affordable.
SMVerified
“I am satisfied with the service”
I received a referral by email, just like from a GP. I did not have to send anything by post and could quickly visit a local blood collection centre. The results were fast and clear. The price was good, not too expensive, and all messages were secure.
kraljicaVerified
“A very good experience”
A very good experience! I received quick answers to my questions, a custom blood test was put together, everything was arranged smoothly, and I could have my blood drawn by a healthcare professional nearby. The results were available within a few days. In short, very satisfied!
PhilVerified
“Very good customer service”
The customer service is very good. I had a complex request, which caused an issue at the blood collection centre. Customer service resolved it very well. They also offer a wide range of tests at a reasonable price.
Marc EekhoutVerified
“Everything was well organised”
Everything was well organised. The products were delivered within a few days and, after sending in the samples, the results arrived within a few days too. Communication and information throughout the process were clear and friendly.
martijnVerified
“Fantastic service”
Fantastic service! Very good customer service that responds quickly and thinks along with you. Good prices. I will definitely use BloedCheckup's services again.
kambalesVerified
“Very happy to have found this business”
Very happy to have found this business. We need to check our blood more often :) The process was easy. They sent me the kit at home, then I had to go to a clinic with the papers and they knew what they had to do. I got the results in less than a week.
DenisaVerified
“Smooth process and good support”
Amazing website experience. I ordered various tests for 2 people. We went to one of the supported centers and took samples. Also after the results were ready, I needed a letter from the laboratory and they prepared the letter for me in no time. Definitely recommended.
Majid HajiheidariVerified
“Amazing service!”
Received a packet with everything needed, went to a walk in clinic (Amsterdam DC Clinic) where my blood was drawn and I was out the door within 5 minutes, and then after posting the samples, received results 2 days later. Results were easy to understand as well. Amazing service, would highly recommend!
Trudi CoetzeeVerified
“Great customer service”
I ordered a test through bloedcheckup.nl but later realized I no longer needed it. I contacted their support team, and they were very quick, responsive, and helpful in handling my cancellation. The whole process was smooth and efficient. Great customer service!
Elif Göksu BecerikVerified