


Holotranscobalamin (HOLO-TC) is a biomarker that measures the amount of vitamin B12 in the body that is directly available for cellular uptake. It is an early indicator of vitamin B12 deficiency, as it only reflects the portion of vitamin B12 that can be actively used by the body.
Testing HOLO-TC is useful for people experiencing symptoms that may indicate a vitamin B12 deficiency, such as fatigue, weakness, memory problems, or neurological changes. It is also valuable for individuals at risk of vitamin B12 deficiency, such as the elderly, vegans, and people with certain stomach conditions or who use specific medications.
HOLO-TC levels indicate the amount of immediately available vitamin B12 in the blood. This helps determine whether the body has sufficient vitamin B12 for essential functions such as DNA synthesis, blood cell production, and nerve maintenance.
A high level of HOLO-TC is generally uncommon and is less frequently associated with health problems. However, in rare cases, it can indicate certain medical conditions or the use of vitamin B12 supplements.
A low level of HOLO-TC indicates a deficiency of available vitamin B12 in the body. This can lead to various health problems, including anemia, nerve damage, fatigue, and cognitive impairments.
Answers to what people usually want to know.
After ordering we generate a referral letter and email you the instructions. You pick a collection point yourself and book an appointment there. Blood is drawn at the location, processed at the lab, and your result arrives digitally.
Usually very quickly. Collection points typically have slots within a few days, sometimes even same-day. It depends on how busy the location is. For a few specialist analyses we first ship collection materials, which takes a bit longer.
At most collection points yes. Some accept walk-ins. This is clearly indicated per location. You choose the location that works best for you.
Holo‑TC; sensitive B12 marker.



€55.00EUR
That depends on the test. Whether fasting is required, and from what time, is clearly stated in the instructions you receive after ordering. No surprises at the counter.
It varies per analysis: from same-day to a few working days. Standard values often come back quickly; analyses that go to an external lab can take a bit longer. You get an email with a link to your digital result, including a short explanation per value.
We work with 1,000+ collection points across the Netherlands. After ordering you'll see which locations near you are available and you pick where you'd like to go.
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