Alpha-1 antitrypsin
Detection of intestinal inflammations, Leaky Gut Syndrome, and food intolerances via Alpha-1-antitrypsin in feces.
Feces Home Test
How it works
- 01
Receive your test kit
Collect a small sample with the spatula
- 02
Take the sample
Place the sample in the provided tube
- 03
Mail back to the lab
Return via medical mail to the lab
Indication: Detection of intestinal inflammations, Leaky Gut Syndrome, and food intolerances.
Alpha-1-antitrypsin (α-1-antitrypsin) is an anti-inflammatory agent, produced in liver and intestinal cells. The liver produces 2 grams per day.
It is an acute-phase protein that, among other things, inhibits inflammatory enzymes and has anti-proteolytic effects. For example, α-1-antitrypsin inhibits the action of the enzyme elastase. Elastase breaks down elastin, an important component of connective tissue. Alpha-1-antitrypsin is measured in feces and is highly suitable for detecting inflammations at a very early stage.
NB: Alpha-1-antitrypsin increases over time as inflammation increases. However, α-1-antitrypsin will decrease if the inflammation increases beyond what α-1-antitrypsin can control. Therefore, the analytical value should always be assessed alongside inflammatory markers such as calprotectin, PMN Elastase, lysozyme, wrCRP and lactoferrin.
Reference Value
|
Alpha-1-antitrypsine |
Max. |
Unit |
|
Reference value |
< 27,5 |
mg/dL |
|
Therapeutic value |
< 24,8 |
mg/dL |
|
Empirical value |
low value may indicate an exhausted response |
|
Interpretation of test results
Elevated value
There is anti-inflammatory activity. Therefore, inflammatory processes are ongoing against which alpha-1-antitrypsin is deployed as an anti-inflammatory agent. This may indicate the presence of intestinal inflammations (ulcerative colitis, Crohn's disease), food intolerances (celiac disease), or increased permeability of the intestinal epithelium (Leaky Gut Syndrome)
Low value
A low value of alpha-1-antitrypsin indicates that there is no anti-inflammatory activity. Therefore, no inflammatory reactions are ongoing, or the inflammatory reactions are greater than the anti-inflammatory capacity. Alpha-1-antitrypsin deficiency can lead to pulmonary emphysema and, to a lesser extent, liver cirrhosis.
Useful additional diagnostics
-Qualitative Inflammation package (hemoglobin, transferrin, calprotectin, lactoferrin)
-Calprotectin (quantitative)
-PMN Elastase
Insufficient evidence in mainstream medicine
The underlying condition or the clinical significance of this test is insufficiently supported within mainstream Dutch medicine.
Rationale for this test
Deze fecale alfa-1-antitrypsine-test wordt aangeboden voor detectie van 'Leaky Gut Syndroom', een ziektebeeld dat niet erkend is binnen de Nederlandse reguliere geneeskunde. Hoewel alfa-1-antitrypsine in feces wel gebruikt wordt in gespecialiseerde centra voor detectie van eiwitverliezende enteropathie, is de toepassing zoals hier beschreven (screening op 'leaky gut', voedingsintoleranties) niet onderbouwd in NHG- of FMS-richtlijnen. De interpretatie-criteria en referentiewaarden zijn niet gevalideerd voor de aangegeven indicaties.
Do not interpret a result from this test as a diagnosis, and always discuss with your GP which regular diagnostics are appropriate for your symptoms.
Independent information sources
We recommend consulting these independent sources before ordering a preventive health check.
- Client brochure PGO (NVvPG, September 2023)
Brochure on preventive health checks: careful choice, reliability, pros and cons, checklist.
- RIVM — Health tests
Independent information about preventive health checks from the National Institute for Public Health and the Environment.
- Thuisarts.nl
Reliable patient information about illnesses and complaints from Dutch GPs (NHG).
- Allesovertesten.nl (NVKC)
Public-facing website of the Dutch Society for Clinical Chemistry with explanations of blood tests and laboratory values.
Frequently asked questions
Answers to what people usually want to know.
View instructionsFull instructions with visual guidanceHow does the stool test work from A to Z?
After ordering we ship the kit to your home. You collect a small sample with the included scoop, keep it cool and return it in the envelope. You receive the result digitally by email.
How do I collect a clean sample?
Lay plastic film over the toilet or use a clean container. Scoop from the middle of the stool and avoid contact with urine or toilet water.
How much stool do I need?
A small scoop with the included spoon is enough — about half a teaspoon. More is not better.
How long can I keep the sample before shipping?
Maximum 24 to 48 hours in the fridge. Send as soon as possible and preferably early in the week, not just before the weekend.
Should I avoid medication or food before collection?
Some analyses (like calprotectin) ask you to avoid NSAIDs or certain supplements 24-48 hours before collection. Check the instructions with your kit for the exact preparation for your test.
When and how do I receive my result?
Stool analyses typically take about a week after the lab receives your sample. You get an email with a link to your digital result, including explanation per value.
How do I return my sample to the lab?
In the included return envelope with free medical shipping. Drop it in the mailbox; the lab processes your sample as soon as it arrives. For some tests it's important to send it the same day — the instructions make this clear.
What if I have questions or something doesn't work?
Feel free to contact us via WhatsApp, email or phone. We're happy to help you before, during or after your test. If the collection doesn't work, we'll arrange a solution or send new materials — no hassle.
Didn't find what you're looking for? Request a custom test
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Received a packet with everything needed, went to a walk in clinic (Amsterdam DC Clinic) where my blood was drawn and I was out the door within 5 minutes, and then after posting the samples, received results 2 days later. Results were easy to understand as well. Amazing service, would highly recommend!