ENA antibodies; autoimmune serology.
Blood collection at collection point
After your order you receive instructions by email
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Blood collection at 1,000+ locations across the Netherlands
ENA screening is a blood test that searches for antibodies against specific extractable nuclear antigens. These antigens are involved in the core processes of cells and can be targeted by the immune system in autoimmune diseases. ENA screening helps in identifying antibodies commonly associated with conditions such as systemic lupus erythematosus (SLE), Sjögren's syndrome, and scleroderma.
ENA screening is crucial for diagnosing various autoimmune diseases. It allows healthcare providers to identify and differentiate specific diseases, which is essential for developing effective treatment and monitoring the progression of the disease over time.
The identification of antibodies against specific extractable nuclear antigens can indicate the presence of an autoimmune disease. The specific antibodies found can assist in pinpointing the exact condition the patient has.
A positive ENA screening indicates the presence of antibodies against one or more extractable nuclear antigens, which can be an indication of an autoimmune disease. The specific antibodies detected can provide information about the type of disease.
A negative ENA screening means that no antibodies against extractable nuclear antigens have been detected. This may suggest the absence of the specific autoimmune diseases tested for, though other tests may be required to refine the diagnosis or rule out other conditions.
This test is included in Dutch healthcare guidelines and is regularly used for its respective indications.
Rationale for this test
ENA-screening is een gevestigde test binnen de Nederlandse reguliere geneeskunde voor de diagnostiek van auto-immuunziekten zoals systemische lupus erythematosus (SLE), Sjögren-syndroom en systemische sclerose. De test is opgenomen in Nederlandse richtlijnen en wordt uitgevoerd volgens NVKC-aanbevelingen. ENA-bepaling wordt standaard geadviseerd na een positieve ANA-test bij verdenking op deze aandoeningen.
Dutch clinical guidelines and healthcare organisations
We recommend consulting these independent sources before ordering a preventive health check.
Brochure on preventive health checks: careful choice, reliability, pros and cons, checklist.
Independent information about preventive health checks from the National Institute for Public Health and the Environment.
Reliable patient information about illnesses and complaints from Dutch GPs (NHG).
Public-facing website of the Dutch Society for Clinical Chemistry with explanations of blood tests and laboratory values.
Answers to what people usually want to know.
After ordering we generate a referral letter and email you the instructions. You pick a collection point yourself and book an appointment there. Blood is drawn at the location, processed at the lab, and your result arrives digitally.
Often within a few working days. How soon you can be seen depends on how busy the location is and the type of analysis. For specialist analyses we first ship collection materials, which takes a bit longer.
At most collection points yes. Some accept walk-ins. This is clearly indicated per location. You choose the location that works best for you.
That depends on the test. Whether fasting is required, and from what time, is clearly stated in the instructions you receive after ordering. No surprises at the counter.
It varies per analysis: from same-day to a few working days. Standard values often come back quickly; analyses that go to an external lab can take a bit longer. You get an email with a link to your digital result, including a short explanation per value.
We work with 1,000+ collection points across the Netherlands. After ordering you'll see which locations near you are available and you pick where you'd like to go.
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