Anti-CCP antibodies for support of early diagnosis of rheumatoid arthritis.
Blood collection at collection point
After your order you receive instructions by email
Make an appointment at a collection point near you
Blood collection at 1,000+ locations across the Netherlands
Anti-CCP stands for antibodies against cyclic citrullinated peptide. These are antibodies (a type of protein) produced by the immune system that are specifically directed against certain proteins in the body that have undergone citrullination, a process that occurs during inflammatory responses. The presence of Anti-CCP is an indicator of rheumatoid arthritis (RA), a chronic autoimmune disease that primarily affects the joints.
Anti-CCP antibodies are highly specific for rheumatoid arthritis and are used for the diagnosis of this condition. Testing for Anti-CCP is useful because it can help establish the diagnosis of rheumatoid arthritis, even in an early stage of the disease. It can also help predict the course of RA and the probability of severe joint damage, which is important for planning effective treatment.
The presence of Anti-CCP antibodies in the blood is a strong indicator of rheumatoid arthritis. High levels of these antibodies are associated with a more aggressive form of the disease and may point to a higher risk of joint damage.
A high level of Anti-CCP antibodies indicates the presence of rheumatoid arthritis and is associated with a more severe disease course. Patients with high levels of Anti-CCP have a higher chance of rapid progression of joint damage and may require more intensive treatment.
A low or non-detectable level of Anti-CCP antibodies does not completely rule out rheumatoid arthritis, but it may indicate a lower likelihood of the disease. It is important to note that RA can also be diagnosed in the absence of Anti-CCP, especially if other clinical symptoms and test results point to RA.
This test is included in Dutch healthcare guidelines and is regularly used for its respective indications.
Rationale for this test
Anti-CCP is een standaard-bepaling in de Nederlandse zorgrichtlijnen voor de diagnose van reumatoïde artritis. De test heeft een hoge specificiteit (vrijwel 100% bij combinatie met reumafactor) en is met name waardevol voor vroege diagnostiek. De klinische betekenis is goed onderbouwd binnen de reguliere geneeskunde.
Dutch clinical guidelines and healthcare organisations
International scientific literature
We recommend consulting these independent sources before ordering a preventive health check.
Brochure on preventive health checks: careful choice, reliability, pros and cons, checklist.
Independent information about preventive health checks from the National Institute for Public Health and the Environment.
Reliable patient information about illnesses and complaints from Dutch GPs (NHG).
Public-facing website of the Dutch Society for Clinical Chemistry with explanations of blood tests and laboratory values.
Answers to what people usually want to know.
After ordering we generate a referral letter and email you the instructions. You pick a collection point yourself and book an appointment there. Blood is drawn at the location, processed at the lab, and your result arrives digitally.
Often within a few working days. How soon you can be seen depends on how busy the location is and the type of analysis. For specialist analyses we first ship collection materials, which takes a bit longer.
At most collection points yes. Some accept walk-ins. This is clearly indicated per location. You choose the location that works best for you.
That depends on the test. Whether fasting is required, and from what time, is clearly stated in the instructions you receive after ordering. No surprises at the counter.
It varies per analysis: from same-day to a few working days. Standard values often come back quickly; analyses that go to an external lab can take a bit longer. You get an email with a link to your digital result, including a short explanation per value.
We work with 1,000+ collection points across the Netherlands. After ordering you'll see which locations near you are available and you pick where you'd like to go.
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