Measure zonulin in stool. Indication for intestinal wall integrity and leaky gut syndrome.
Feces Home Test
Collect a small sample with the spatula
Place the sample in the provided tube
Return via medical mail to the lab
Zonulin is a protein that is active in the intestinal epithelium. Zonulin reacts to exposure to gliadin and pathogenic bacteria. Gliadin, together with glutenin, forms the protein gluten.
As soon as zonulin is released by the epithelial cells, it is signaled by Immunoglobulin A, after which a reaction of the intestinal wall follows. The tight junction proteins between the cells of the intestinal wall loosen or break. The gliadins or pathogenic bacteria can now pass through the intestinal wall, after which dendritic cells, via the antigen-presenting cells, trigger T-cell activation.
This immune response causes inflammation of the cells of the intestinal wall, after which zonulin, tight junction proteins, pathogens, bacterial lipopolysaccharides, and inflammatory mediating cytokines can enter the lamina propria from the intestines. Subsequently, these substances enter the bloodstream, where they can induce neuroinflammation.
The underlying condition or the clinical significance of this test is insufficiently supported within mainstream Dutch medicine.
Rationale for this test
De zonuline-test in ontlasting wordt binnen de Nederlandse reguliere geneeskunde niet onderbouwd. Het onderliggende concept 'leaky gut syndroom' is geen erkend ziektebeeld in de reguliere zorg. De wetenschappelijke basis voor zonuline-meting als diagnosticum voor darmwandintegriteit is onvoldoende, en de test is niet opgenomen in NHG- of FMS-richtlijnen.
Do not interpret a result from this test as a diagnosis, and always discuss with your GP which regular diagnostics are appropriate for your symptoms.
International scientific literature
We recommend consulting these independent sources before ordering a preventive health check.
Brochure on preventive health checks: careful choice, reliability, pros and cons, checklist.
Independent information about preventive health checks from the National Institute for Public Health and the Environment.
Reliable patient information about illnesses and complaints from Dutch GPs (NHG).
Public-facing website of the Dutch Society for Clinical Chemistry with explanations of blood tests and laboratory values.
Practical information
After ordering we ship the kit to your home. You collect a small sample with the included scoop, keep it cool and return it in the envelope. You receive the result digitally by email.
Lay plastic film over the toilet or use a clean container. Scoop from the middle of the stool and avoid contact with urine or toilet water.
A small scoop with the included spoon is enough — about half a teaspoon. More is not better.
Maximum 24 to 48 hours in the fridge. Send as soon as possible and preferably early in the week, not just before the weekend.
Some analyses (like calprotectin) ask you to avoid NSAIDs or certain supplements 24-48 hours before collection. Check the instructions with your kit for the exact preparation for your test.
Stool analyses typically take about a week after the lab receives your sample. You receive your laboratory report securely by email. It lists the measured values, units, reference ranges and any flags added by the laboratory.
Use the supplied return envelope and place it in the letter-mail bag inside a PostNL service point yourself as soon as possible. Do not hand it to counter staff or request track & trace. The instructions supplied with your test state when it must be sent.
Feel free to contact us via WhatsApp, email or phone. We're happy to help you before, during or after your test. If the collection doesn't work, we'll arrange a solution or send new materials — no hassle.
“Very positive experience”
From ordering to having my blood drawn, everything went smoothly and was well organised. I really appreciated being able to visit a blood collection location in my own town so quickly. I received clear instructions beforehand, and the results arrived promptly by email too. Very satisfied!
“Good communication”
This company responds to questions thoroughly and promptly. The entire process, from requesting the test to having blood drawn and receiving the results, runs very smoothly. Overall, I am very satisfied!
“Wide choice of tests, fast and affordable”
You can choose the tests yourself. Fast delivery and processing, clear instructions and affordable.
“I am satisfied with the service”
I received a referral by email, just like from a GP. I did not have to send anything by post and could quickly visit a local blood collection centre. The results were fast and clear. The price was good, not too expensive, and all messages were secure.
“A very good experience”
A very good experience! I received quick answers to my questions, a custom blood test was put together, everything was arranged smoothly, and I could have my blood drawn by a healthcare professional nearby. The results were available within a few days. In short, very satisfied!
“Very good customer service”
The customer service is very good. I had a complex request, which caused an issue at the blood collection centre. Customer service resolved it very well. They also offer a wide range of tests at a reasonable price.
“Everything was well organised”
Everything was well organised. The products were delivered within a few days and, after sending in the samples, the results arrived within a few days too. Communication and information throughout the process were clear and friendly.
“Fantastic service”
Fantastic service! Very good customer service that responds quickly and thinks along with you. Good prices. I will definitely use BloedCheckup's services again.
“Very happy to have found this business”
Very happy to have found this business. We need to check our blood more often :) The process was easy. They sent me the kit at home, then I had to go to a clinic with the papers and they knew what they had to do. I got the results in less than a week.
“Smooth process and good support”
Amazing website experience. I ordered various tests for 2 people. We went to one of the supported centers and took samples. Also after the results were ready, I needed a letter from the laboratory and they prepared the letter for me in no time. Definitely recommended.
“Amazing service!”
Received a packet with everything needed, went to a walk in clinic (Amsterdam DC Clinic) where my blood was drawn and I was out the door within 5 minutes, and then after posting the samples, received results 2 days later. Results were easy to understand as well. Amazing service, would highly recommend!
“Great customer service”
I ordered a test through bloedcheckup.nl but later realized I no longer needed it. I contacted their support team, and they were very quick, responsive, and helpful in handling my cancellation. The whole process was smooth and efficient. Great customer service!