
Blood draw
Vegan Test
Panel for vegetarian or vegan diet; B12 D iron and more.
€ 116,00
Your privacy
Necessary cookies keep the website working.
With your consent, we use additional cookies to:
We may share visited pages, interactions and device data with 5 service providers.
Hashed contact details are shared only with marketing consent.
You can change this later through Cookie preferences at the bottom of every page.
More information is available in our privacy policy.
Vitamins, minerals and amino acids · Blood
The calcium in your blood; an abnormality is usually related to the parathyroid gland, vitamin D, the kidneys or the protein albumin.
At a glance
Explanation
Calcium is mainly found in the bones and teeth; the small part in the blood is needed for muscles, nerves and blood clotting. This analysis measures total calcium in the blood: the free, active part plus the part bound to proteins, mainly albumin. Parathyroid hormone (PTH) and vitamin D keep the value within narrow limits, by releasing calcium from the bones or absorbing more calcium from the intestine. The result therefore says nothing about how much calcium is in your bones or how much you take in through food.
Result
A raised calcium (hypercalcemia) in someone without symptoms is most often due to an overactive parathyroid gland (primary hyperparathyroidism). Usually there is then a benign small growth in one of the parathyroid glands, which as a result makes too much parathyroid hormone (PTH). Other causes are high doses of vitamin D, a lot of calcium tablets or antacid tablets containing calcium, thiazide-type diuretics, lithium, an overactive thyroid, sarcoidosis and being bedridden for a long time. A slightly raised value often causes no symptoms; at higher values, thirst, frequent urination, tiredness, nausea, constipation, kidney stones and confusion can develop. Rarely: a malignant condition, such as metastases in the bone or multiple myeloma (Kahler's disease, a bone marrow disease).
A low total calcium is usually due to a low albumin in the blood. The free, active calcium is then normal and calcium balance is not disturbed; that is why calcium is always assessed together with albumin. A truly low calcium fits a deficiency of vitamin D, reduced kidney function, a magnesium deficiency, poor absorption in the intestine or an underactive parathyroid gland, for example after surgery on the neck. Symptoms that may go with it are tingling in the fingers and around the mouth, muscle cramps and muscle twitches.
With a raised calcium, the GP repeats the measurement together with albumin, phosphate, kidney function and parathyroid hormone (PTH). If the result fits an overactive parathyroid gland, referral to an internist (specialist in internal medicine) usually follows. With a low calcium, the GP looks at albumin, vitamin D, magnesium and kidney function.
Reliability
The measurement of total calcium is accurate, but a single value is hard to interpret without albumin, because a large part of the calcium is bound to this protein. According to the Dutch Society for Clinical Chemistry (NVKC) and the Acute Boekje of the Dutch internists, an abnormal value is assessed together with albumin, phosphate, magnesium, kidney function and, if needed, PTH and vitamin D.
Who it is for
The result is most meaningful with symptoms that may fit calcium that is too high (thirst, frequent urination, tiredness, constipation, kidney stones) or too low (tingling, muscle cramps), with bone loss, with use of high doses of vitamin D or calcium, with use of thiazide diuretics or lithium and with reduced kidney function. In healthy people without symptoms, a slightly abnormal value is often due to the albumin or the blood draw. If you eat a vegan diet, for example, and want to know whether your calcium intake is sufficient, this measurement is of little use: the body keeps calcium in the blood stable, even with a low intake.
An overactive parathyroid gland (primary hyperparathyroidism), the main cause of a raised calcium in people without symptoms, occurs in about 1 in 100 people. The condition often causes few symptoms, so a raised calcium is sometimes the first clue. A truly low calcium is rare in healthy adults; it is then usually a low albumin.
LUMC (patient information on hyperparathyroidism) and NVKC
Get tested
Calcium is part of these test panels. You order online and have your blood drawn at a collection point or collect the sample at home.

Blood draw
Panel for vegetarian or vegan diet; B12 D iron and more.
€ 116,00

Fingerstick
Serum calcium for bone metabolism and parathyroid gland function.
€ 23,00

Blood draw
Serum calcium in bone metabolism and parathyroid function.
€ 23,00
Blood draw
InsideTracker Blood Analysis: analyze 48 biomarkers for complete health optimization and personalized recommendations.
€ 335,00

Blood draw
Comprehensive blood analysis with biomarkers that integrates directly with your WHOOP wearable for optimal performance and recovery.
€ 385,00
Evidence
This explanation is based on Dutch guidelines and independent information. It is general information, not a diagnosis. Discuss an abnormal result with your GP.
More about risks and resultsMore explanations