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Vitamins, minerals and amino acids · Blood

Magnesium

The magnesium in your blood; mainly shows large deficiencies or excesses and says little about the store in your body.

At a glance

  • Measured in blood
  • In 5 test panels
  • No special preparation

Magnesium

  • Explanation
  • Result
  • Reliability
  • Who it is for
  • Test panels
  • Sources

Explanation

Magnesium: what is measured?

Magnesium is a mineral needed for muscles, nerves, bones and energy production in cells. About half is in the bones and the rest mainly in cells, muscles and organs; only about 1 percent is in the blood. The intestines and kidneys keep the amount in the blood within narrow limits by absorbing and excreting more or less. This analysis measures the magnesium in serum.

What can it detect?

  • A magnesium level that is too low (hypomagnesemia) due to loss or poor absorption, for example with prolonged diarrhea, water pills (diuretics), stomach acid inhibitors (proton pump inhibitors), bowel diseases or a lot of alcohol
  • A magnesium level that is too high (hypermagnesemia), mainly with reduced kidney function or use of laxatives containing magnesium
  • A possible explanation for a persistently low potassium or calcium

Result

What does the result mean?

Magnesium too high

According to the Dutch Society for Clinical Chemistry (NVKC), a raised magnesium is rarely caused by diet. It is usually due to reduced kidney function, which makes the body less able to get rid of magnesium, or to magnesium from laxatives or high-dose supplements. Dehydration can also raise the value. A slightly raised value usually causes no symptoms. With a finger prick or a difficult blood draw, damaged blood cells (hemolysis) can release magnesium, making the result falsely high.

Magnesium too low

A low magnesium mainly results from loss or poor absorption: prolonged diarrhea, a lot of alcohol, malnutrition, bowel diseases such as Crohn's disease, water pills (diuretics), long-term use of stomach acid inhibitors (proton pump inhibitors) and poorly controlled diabetes. According to Het Acute Boekje of the Dutch internists, symptoms usually only appear at a strongly low value (below 0.5 mmol/l), often because potassium and calcium then also fall: muscle weakness, trembling, cramps and heart rhythm disorders. Vague symptoms such as tiredness or muscle cramps usually have another cause; according to Thuisarts, magnesium does not help against nighttime calf cramps, except sometimes during pregnancy. A normal value does not rule out a small deficiency in the cells.

After an abnormal result

With a low magnesium, the GP looks at medicines (water pills, stomach acid inhibitors), alcohol use and bowel symptoms, and usually also measures potassium, calcium and kidney function. With a raised magnesium, kidney function is checked and the use of laxatives or supplements is asked about.

Reliability

How reliable is the test?

The measurement itself is reliable, but serum magnesium poorly reflects the store in the body, because only about 1 percent of the magnesium is in the blood and the body keeps that value stable. The Netherlands Nutrition Centre (Voedingscentrum) therefore writes that the blood value is not a good measure for establishing a magnesium deficiency. The measurement is mainly useful with illness, medicine use or an abnormal potassium or calcium. There is no Dutch GP guideline (NHG) that recommends measuring magnesium in people without symptoms.

What can affect the result?

  • Hemolysis due to a finger prick, prolonged use of a tourniquet or a difficult blood draw can falsely raise the value.
  • Magnesium supplements and laxatives raise the value; water pills (diuretics) and stomach acid inhibitors can lower it.
  • Reference values differ between laboratories.

Who it is for

Who is the test useful for?

Useful for

Useful with prolonged diarrhea or a bowel disease, heavy alcohol use, malnutrition, long-term use of water pills (diuretics) or stomach acid inhibitors (proton pump inhibitors), reduced kidney function and a persistently low potassium or calcium. With tiredness or muscle cramps without these risk factors, the measurement is of little use, because a deficiency is rarely the cause and the blood value does not show a small deficiency well. A vegetarian diet is also not expected to cause a deficiency, because magnesium is abundant in plant-based products.

How common is it?

How often a low magnesium occurs in healthy Dutch people is not known. According to the Netherlands Nutrition Centre (Voedingscentrum), a deficiency does not occur easily, because magnesium is found in many foods, such as whole grain products, vegetables, nuts and dairy products. A low magnesium is mainly seen with bowel or kidney problems, a lot of alcohol and long-term use of water pills or stomach acid inhibitors.

The Netherlands Nutrition Centre (Voedingscentrum), the NVKC and Het Acute Boekje (Netherlands Internists Association)

Drawbacks and risks

  • A slightly abnormal result is easily seen as the explanation for vague symptoms such as tiredness or cramps; this can lead to unnecessary supplement use while another cause is missed.
  • According to the Netherlands Nutrition Centre (Voedingscentrum), more than 250 milligrams of magnesium per day from supplements can cause diarrhea.

Get tested

Magnesium: test panels

Magnesium is part of these test panels. You order online and have your blood drawn at a collection point or collect the sample at home.

  • Magnesium

    Blood draw

    Magnesium

    Serum magnesium; electrolyte balance.

    € 32,00

  • Magnesium (fingerstick)

    Fingerstick

    Magnesium

    Serum magnesium; for insight into magnesium and electrolyte balance.

    € 32,00

  • InsideTracker

    Blood draw

    InsideTracker

    InsideTracker Blood Analysis: analyze 48 biomarkers for complete health optimization and personalized recommendations.

    € 335,00

  • Vegetarian Extensive

    Blood draw

    Vegetarian Extensive

    Iron, ferritin, B12 total and active, vitamin D, folic acid, zinc, magnesium, hemoglobin, and hematocrit. Complete nutritional status check.

    € 269,00

  • Fatigue Basic

    Blood draw

    Fatigue Basic

    Vitamin D, B12, TSH, fT4, glucose, hemoglobin, MCV, iron, and magnesium. Tests most common causes of fatigue.

    € 116,00

Evidence

Sources

This explanation is based on Dutch guidelines and independent information. It is general information, not a diagnosis. Discuss an abnormal result with your GP.

More about risks and results
  • NVKC, allesovertesten.nl: Magnesium
  • Voedingscentrum: Magnesium
  • Nederlandse Internisten Vereniging, Het Acute Boekje: Hypomagnesiëmie
  • Thuisarts.nl: Ik heb 's nachts vaak kramp in mijn kuit

More explanations

Other tests: Vitamins, minerals and amino acids

  • AC/FC ratio
  • Acylcarnitine
  • Alanine
  • Antibodies against intrinsic factor
  • Arginine
  • Calcium
  • Calcium (albumin-corrected)
  • Carnitine, free
  • Carnitine, total
  • Coenzyme Q10
  • Copper
  • Folic acid
All tests
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